Efficacy and Safety of a Balanced Salt Solution Versus a 0.9% Saline Infusion for the Prevention of Contrast-Induced Acute Kidney Injury After Contrast-Enhanced Computed Tomography.

ABSTRACT:

Rationale & objective

We aimed to elucidate whether a balanced salt solution decreases the occurrence of contrast-induced acute kidney injury (CI-AKI) after contrast-enhanced computed tomography (CE-CT) as compared to 0.9% saline solution.

Study design

A randomized clinical trial.

Setting & participants

The study was performed in 14 tertiary hospitals in South Korea. Patients with estimated glomerular filtration rates (eGFRs) < 45 or <60 mL/min/1.73 m² and additional risk factors (age ≥ 60 years or diabetes) who were undergoing scheduled CE-CT were included from December 2016 to December 2018.

Intervention

An open-label intervention was performed. The study group received a balanced salt solution and the control group received 0.9% saline solution as

SUBMITTER: Park S 

PROVIDER: S-EPMC7380376 | biostudies-literature | 2020 Mar-Apr

REPOSITORIES: biostudies-literature