Efficacy of a Moisturizer for Pruritus Accompanied With Asteatosis in Dialysis Patients: An Open-Label, Randomized, Exploratory Study.

ABSTRACT:

Background

In dialysis patients, skin disorders (dryness and itching) are frequently observed and treated with a moisturizer, in the absence of clear evidence of efficacy.

Study design

An open-label, randomized, before/after, parallel-group, comparative/exploratory study.

Setting & participants

12 Japanese patients with chronic kidney failure undergoing maintenance hemodialysis who presented with dry skin and itching.

Intervention

Patients received a topical heparinoid moisturizer as the study drug for 2 weeks from the first day of the study treatment, followed by either a 2-week washout (group A: 6 participants) or further 2-week treatment (group B: 6 participants).

Outcomes

The primary end point was change in water content in the stratum corneum in the

SUBMITTER: Yoshida Y 

PROVIDER: S-EPMC7380392 | biostudies-literature | 2019 Jul-Aug

REPOSITORIES: biostudies-literature