Cognitive dispersion is a sensitive marker for early neurodegenerative changes and functional decline in nondemented older adults.

ABSTRACT:

Objective

Intraindividual cognitive variability (IIV), a measure of within-person variability across cognitive measures at a single time point, is associated with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Little is known regarding brain changes underlying IIV, or the relationship between IIV and functional ability. Therefore, we investigated the association between IIV and cerebral atrophy in AD-vulnerable regions and everyday functioning in nondemented older adults.

Method

736 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (285 cognitively normal [CN]; 451 MCI) underwent neuropsychological testing and serial MRI over 2 years. Linear mixed effects models examined the association between baseline IIV and change in entorhinal cortex thickne

SUBMITTER: Bangen KJ 

PROVIDER: S-EPMC7380511 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature