Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children.

ABSTRACT: Microbiome sequence analyses have suggested that changes in gut bacterial composition are associated with autoimmune disease in humans and animal models. However, little is known of the mechanisms through which the gut microbiota influences autoimmune responses to distant tissues. Here, we evaluated systemic antibody responses against cultured human gut bacterial strains to determine whether observed patterns of anticommensal antibody (ACAb) responses are associated with type 1 diabetes (T1D) in two cohorts of pediatric study participants. In the first cohort, ACAb responses in sera collected from participants within 6 months of T1D diagnosis were compared with age-matched healthy controls and also with patients with recent onset Crohn's disease. ACAb responses against multiple bacterial s

SUBMITTER: Paun A 

PROVIDER: S-EPMC7380548 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature