Genomewide Stabilization of mRNA during a "Feast-to-Famine" Growth Transition in Escherichia coli.

ABSTRACT: Bacteria have to continuously adjust to nutrient fluctuations from favorable to less-favorable conditions and in response to carbon starvation. The glucose-acetate transition followed by carbon starvation is representative of such carbon fluctuations observed in Escherichia coli in many environments. Regulation of gene expression through fine-tuning of mRNA pools constitutes one of the regulation levels required for such a metabolic adaptation. It results from both mRNA transcription and degradation controls. However, the contribution of transcript stability regulation in gene expression is poorly characterized. Using combined transcriptome and mRNA decay analyses, we investigated (i) how transcript stability changes in E. coli during the glucose-acetate-starvation transition

SUBMITTER: Morin M 

PROVIDER: S-EPMC7380570 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature