Cryo-electron microscopy structure of CLHM1 ion channel from Caenorhabditis elegans.

ABSTRACT: Calcium homeostasis modulators (CALHMs/CLHMs) comprise a family of pore-forming protein complexes assembling into voltage-gated, Ca²⁺ -sensitive, nonselective channels. These complexes contain an ion-conduction pore sufficiently wide to permit the passing of ATP molecules serving as neurotransmitters. While their function and structure information is accumulating, the precise mechanisms of these channel complexes remain to be full understood. Here, we present the structure of the Caenorhabditis elegans CLHM1 channel in its open state solved through single-particle cryo-electron microscopy at 3.7-Å resolution. The transmembrane region of the channel structure of the dominant class shows an assembly of 10-fold rotational symmetry in one layer, and its cytoplasmic region is involve

SUBMITTER: Yang W 

PROVIDER: S-EPMC7380676 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature