Ontology highlight
ABSTRACT:
SUBMITTER: Bolado-Carrancio A
PROVIDER: S-EPMC7380942 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
eLife 20200724
Migrating cells need to coordinate distinct leading and trailing edge dynamics but the underlying mechanisms are unclear. Here, we combine experiments and mathematical modeling to elaborate the minimal autonomous biochemical machinery necessary and sufficient for this dynamic coordination and cell movement. RhoA activates Rac1 via DIA and inhibits Rac1 via ROCK, while Rac1 inhibits RhoA through PAK. Our data suggest that in motile, polarized cells, RhoA-ROCK interactions prevail at the rear, whe ...[more]