Striatin Is Required for Hearing and Affects Inner Hair Cells and Ribbon Synapses.

ABSTRACT: Striatin, a subunit of the serine/threonine phosphatase PP2A, is a core member of the conserved striatin-interacting phosphatase and kinase (STRIPAK) complexes. The protein is expressed in the cell junctions between epithelial cells, which play a role in maintaining cell-cell adhesion. Since the cell junctions are crucial for the function of the mammalian inner ear, we examined the localization and function of striatin in the mouse cochlea. Our results show that in neonatal mice, striatin is specifically expressed in the cell-cell junctions of the inner hair cells, the receptor cells in the mammalian cochlea. Auditory brainstem response measurements of striatin-deficient mice indicated a progressive, high-frequency hearing loss, suggesting that striatin is essential for normal hearing. Mor

SUBMITTER: Nadar-Ponniah PT 

PROVIDER: S-EPMC7381154 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature