Experimental Control of Macrophage Pro-Inflammatory Dynamics Using Predictive Models.

ABSTRACT: Macrophage activity is a major component of the healthy response to infection and injury that consists of tightly regulated early pro-inflammatory activation followed by anti-inflammatory and regenerative activity. In numerous diseases, however, macrophage polarization becomes dysregulated and can not only impair recovery, but can promote further injury and pathogenesis, e.g., after trauma or in diabetic ulcers. Dysregulated macrophages may either fail to polarize or become chronically polarized, resulting in increased production of cytotoxic factors, diminished capacity to clear pathogens, or failure to promote tissue regeneration. In these cases, a method of predicting and dynamically controlling macrophage polarization will enable a new strategy for treating diverse inflammatory disease

SUBMITTER: Weinstock LD 

PROVIDER: S-EPMC7381235 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature