Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice.

ABSTRACT:

Background

Shexiang Baoxin Pill (SBP), a formulated traditional Chinese medicine (TCM), has been widely used to treat cardiovascular diseases for years. This herbal mixture has been shown to promote differentiation of cultured neuronal cells. Here, we aimed to investigate the effects of SBP in attenuating cognitive impairment in APP/PS1 transgenic mice.

Methods

Ethanol and water extracts of SBP, denoted as SBP_EtOH and SBP_water, were standardized and applied onto cultured rat pheochromocytoma PC12 cells. The potential effect of SBP_EtOH extract in attenuating the cognitive impairments in APP/PS1 transgenic mice was shown by following lines of evidence: (i) inhibition of Aβ fibril formation, (ii) suppression of secretions of cytokines, and (iii)

SUBMITTER: Hu WH 

PROVIDER: S-EPMC7381243 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature