In vivo Regeneration of Mineralized Bone Tissue in Anisotropic Biomimetic Sponges.

ABSTRACT: In the last two decades, alginate scaffolds have been variously studied as extracellular matrix analogs for tissue engineering. However, relevant evidence is still lacking concerning their ability to mimic the microenvironment of hierarchical tissues such as bone. Hence, an increasing amount of attention has recently been devoted to the fabrication of macro/microporous sponges with pore anisotropy able to more accurately replicate the cell niche structure as a trigger for bioactive functionalities. This paper presents an in vivo study of alginate sponges with anisotropic microporous domains (MAS) formed by ionic crosslinking in the presence of different fractions (30 or 50% v) of hydroxyapatite (HA). In comparison with unloaded sponges (MAS0), we demonstrated that HA confers peculiar physi

SUBMITTER: Serrano-Bello J 

PROVIDER: S-EPMC7381345 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature