Vitamin D intake is associated with decreased risk of immune checkpoint inhibitor-induced colitis.

ABSTRACT:

Background

There is a lack of predictive markers informing on the risk of colitis in patients treated with immune checkpoint inhibitors (ICIs). The aim of this study was to identify potential factors associated with development of ICI colitis.

Methods

We performed a retrospective analysis of melanoma patients at Dana-Farber Cancer Institute who received PD-1, CTLA-4, or combination ICIs between May 2011 to October 2017. Clinical and laboratory characteristics associated with pathologically confirmed ICI colitis were evaluated using multivariable logistic regression analyses. External confirmation was performed on an independent cohort from Massachusetts General Hospital.

Results

The discovery cohort included 213 patients of whom 37 developed ICI colitis (17%). Vitamin

SUBMITTER: Grover S 

PROVIDER: S-EPMC7381363 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature