Ontology highlight
ABSTRACT:
SUBMITTER: Wandel MP
PROVIDER: S-EPMC7381384 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Wandel Michal P MP Kim Bae-Hoon BH Park Eui-Soon ES Boyle Keith B KB Nayak Komal K Lagrange Brice B Herod Adrian A Henry Thomas T Zilbauer Matthias M Rohde John J MacMicking John D JD Randow Felix F
Nature immunology 20200615 8
Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unknown. Here we show that in interferon-γ-stimulated cells guanylate-binding proteins (GBPs) assemble on the surface of Gram-negative bacteria into polyvalent signaling platforms required for activation of caspase-4. Caspase-4 activation is hierarchically contr ...[more]