Epidemiology and burden of sepsis acquired in hospitals and intensive care units: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Sepsis is recognized as a global public health problem, but the proportion due to hospital-acquired infections remains unclear. We aimed to summarize the epidemiological evidence related to the burden of hospital-acquired (HA) and ICU-acquired (ICU-A) sepsis.

Methods

We searched MEDLINE, Embase and the Global Index Medicus from 01/2000 to 03/2018. We included studies conducted hospital-wide or in intensive care units (ICUs), including neonatal units (NICUs), with data on the incidence/prevalence of HA and ICU-A sepsis and the proportion of community and hospital/ICU origin. We did random-effects meta-analyses to obtain pooled estimates; inter-study heterogeneity and risk of bias were assessed.

Results

Of the 13,239 studies identified, 51 met the inclusion crit

SUBMITTER: Markwart R 

PROVIDER: S-EPMC7381455 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature