Associations between small and middle molecules clearance and the change of cognitive function in peritoneal dialysis.

ABSTRACT:

Background

Uremic toxins have been suspected as potential contributors for cognitive impairment in peritoneal dialysis (PD) patients. However, associations between the clearance of serum small and middle molecules and the change of cognitive function were not fully explored and then we explored this issue in the present study.

Method

A total of clinically-stable 222 patients on PD were enrolled and then followed up for 2 years in this single-center prospective cohort study. Small and middle molecules clearances were examined by urea clearance (Kt/V), creatinine clearance (Ccr) and beta-2 microglobulin (B2M) clearance via dialysate and urine at baseline and after 2 years. Global and specific cognitive impairment were measured at baseline and after 2 years. Modified Mini-Menta

SUBMITTER: Li Y 

PROVIDER: S-EPMC7381472 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature