Propionate supplementation promotes the expansion of peripheral regulatory T-Cells in patients with end-stage renal disease.

ABSTRACT: Patients with end-stage renal disease (ESRD) suffer from a progressively increasing low-grade systemic inflammation, which is associated with higher morbidity and mortality. Regulatory T cells (Tregs) play an important role in regulation of the inflammatory process. Previously, it has been demonstrated that short-chain fatty acids reduce inflammation in the central nervous system in a murine model of multiple sclerosis through an increase in tissue infiltrating Tregs. Here, we evaluated the effect of the short-chain fatty acid propionate on the chronic inflammatory state and T-cell composition in ESRD patients. Analyzing ESRD patients and healthy blood donors before, during, and 60 days after the propionate supplementation by multiparametric flow cytometry we observed a gradual and signifi

SUBMITTER: Meyer F 

PROVIDER: S-EPMC7381474 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature