A three-marker protein biosignature distinguishes tuberculosis from other respiratory diseases in Gambian children.

ABSTRACT:

Background

Our study aimed to identify a host cytokine biosignature that could distinguish childhood tuberculosis (TB) from other respiratory diseases (OD).

Methods

Cytokine responses in prospectively recruited children with symptoms suggestive of TB were measured in whole blood assay supernatants, harvested after overnight incubation, using a Luminex platform. We used logistic regression models with Least Absolute Shrinkage and Selection Operator (LASSO) penalty to identify the optimal biosignature associated with confirmed TB disease in the training set. We subsequently assessed its performance in the test set.

Findings

Of the 431 children included in the study, 44 had bacteriologically confirmed TB, 60 had clinically diagnosed TB while 327 had OD. All children were

SUBMITTER: Togun T 

PROVIDER: S-EPMC7381493 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature