Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis.

ABSTRACT:

Background

High-molecular-weight kininogen is a cofactor of the human contact system, an inflammatory response mechanism that is activated during sepsis. It has been shown that high-molecular-weight kininogen contributes to endotoxemia, but is not critical for local host defense during pneumonia by Gram-negative bacteria. However, some important pathogens, such as Streptococcus pyogenes, can cleave kininogen by contact system activation. Whether kininogen causally affects antibacterial host defense in S. pyogenes infection, remains unknown.

Methods

Kininogen concentration was determined in course plasma samples from septic patients. mRNA expression and degradation of kininogen was determined in liver or plasma of septic mice. Kininogen was depleted in mice by treatment with

SUBMITTER: Kohler J 

PROVIDER: S-EPMC7381504 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature