Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer.

ABSTRACT: Esophageal squamous cell carcinoma (ESCC) is prevalent in some geographical regions of the world. ESCC development presents a multistep pathogenic process from inflammation to invasive cancer; however, what is critical in these processes and how they evolve is largely unknown, obstructing early diagnosis and effective treatment. Here, we create a mouse model mimicking human ESCC development and construct a single-cell ESCC developmental atlas. We identify a set of key transitional signatures associated with oncogenic evolution of epithelial cells and depict the landmark dynamic tumorigenic trajectories. An early downregulation of CD8⁺ response against the initial tissue damage accompanied by the transition of immune response from type 1 to type 3 results in accumulation and acti

SUBMITTER: Yao J 

PROVIDER: S-EPMC7381637 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature