Preparation of TiH_1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy.

ABSTRACT: Metal hydrides have been rarely used in biomedicine. Herein, we fabricate titanium hydride (TiH_1.924) nanodots from its powder form via the liquid-phase exfoliation, and apply these metal hydride nanodots for effective cancer treatment. The liquid-phase exfoliation is an effective method to synthesize these metal hydride nanomaterials, and its efficiency is determined by the matching of surface energy between the solvent and the metal hydrides. The obtained TiH_1.924 nanodots can produce reactive oxygen species (ROS) under ultrasound, presenting a highly efficient sono-sensitizing effect. Meanwhile, TiH_1.924 nanodots with strong near-infrared (NIR) absorbance can serve as a robust photothermal agent. By using the mild photothermal effect to enhance intra-tum

SUBMITTER: Gong F 

PROVIDER: S-EPMC7381661 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature