Cerebellar-cortical function and connectivity during sensorimotor behavior in aging FMR1 gene premutation carriers.

ABSTRACT:

Introduction

Premutation carriers of the FMR1 gene are at risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disease characterized by motor, cognitive, and psychiatric decline as well as cerebellar and cerebral white matter pathology. Several studies have documented preclinical sensorimotor issues in aging premutation carriers, but the extent to which sensorimotor brain systems are affected and may represent early indicators of atypical neurodegeneration has not been determined.

Materials and methods

Eighteen healthy controls and 16 FMR1 premutation carriers (including five with possible, probable, or definite FXTAS) group-matched on age, sex, and handedness completed a visually guided precision gripping task with their right hand dur

SUBMITTER: McKinney WS 

PROVIDER: S-EPMC7381687 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature