Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy.

ABSTRACT: Dysregulated inflammation is a complicated pathological process involved in various diseases, and the treatment of inflammation-linked disorders currently represents an enormous global burden. Extracellular vesicles (EVs) are nanosized, lipid membrane-enclosed vesicles secreted by virtually all types of cells, which act as an important intercellular communicative medium. Considering their capacity to transfer bioactive substances, both unmodified and engineered EVs are increasingly being explored as potential therapeutic agents or therapeutic vehicles. Moreover, as the nature's own delivery tool, EVs possess many desirable advantages, such as stability, biocompatibility, low immunogenicity, low toxicity, and biological barrier permeability. The application of EV-based therapy to combat inf

SUBMITTER: Tang TT 

PROVIDER: S-EPMC7381724 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature