The Summit Score Stratifies Mortality and Morbidity in Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Introduction

Tobacco use and other cardiovascular risk factors often accompany chronic obstructive pulmonary disease (COPD). This study derived and validated the Summit Score to predict mortality in people with COPD and cardiovascular risks.

Methods

SUMMIT trial subjects (N=16,485) ages 40-80 years with COPD were randomly assigned 50%/50% to derivation (N=8181) and internal validation (N=8304). Three external COPD validations from Intermountain Healthcare included outpatients with cardiovascular risks (N=9251), outpatients without cardiovascular risks (N=8551), and inpatients (N=26,170). Cox regression evaluated 40 predictors of all-cause mortality. SUMMIT treatments including combined fluticasone furoate (FF) 100μg/vilanterol 25μg (VI) were not included in the score.

Res

SUBMITTER: Horne BD 

PROVIDER: S-EPMC7381787 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature