Human cord blood-derived regulatory T-cell therapy modulates the central and peripheral immune response after traumatic brain injury.

ABSTRACT: Traumatic brain injury (TBI) causes a profound inflammatory response within the central nervous system and peripheral immune system, which contributes to secondary brain injury and further morbidity and mortality. Preclinical investigations have demonstrated that treatments that downregulate microglia activation and polarize them toward a reparative/anti-inflammatory phenotype have improved outcomes in preclinical models. However, no therapy to date has translated into proven benefits in human patients. Regulatory T cells (Treg) have been shown to downregulate pathologic immune responses of the innate and adaptive immune system across a variety of pathologies. Furthermore, cellular therapy has been shown to augment host Treg responses in preclinical models; yet, studies investigating the u

SUBMITTER: Caplan HW 

PROVIDER: S-EPMC7381810 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature