Presence of Genetic Variants Among Young Men With Severe COVID-19.

ABSTRACT:

Importance

Severe coronavirus disease 2019 (COVID-19) can occur in younger, predominantly male, patients without preexisting medical conditions. Some individuals may have primary immunodeficiencies that predispose to severe infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Objective

To explore the presence of genetic variants associated with primary immunodeficiencies among young patients with COVID-19.

Design, setting, and participants

Case series of pairs of brothers without medical history meeting the selection criteria of young (age <35 years) brother pairs admitted to the intensive care unit (ICU) due to severe COVID-19. Four men from 2 unrelated families were admitted to the ICUs of 4 hospitals in the Netherlands between March 23

SUBMITTER: van der Made CI 

PROVIDER: S-EPMC7382021 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature