The use of restricted mean time lost under competing risks data.

ABSTRACT:

Background

Under competing risks, the commonly used sub-distribution hazard ratio (SHR) is not easy to interpret clinically and is valid only under the proportional sub-distribution hazard (SDH) assumption. This paper introduces an alternative statistical measure: the restricted mean time lost (RMTL).

Methods

First, the definition and estimation methods of the measures are introduced. Second, based on the differences in RMTLs, a basic difference test (Diff) and a supremum difference test (sDiff) are constructed. Then, the corresponding sample size estimation method is proposed. The statistical properties of the methods and the estimated sample size are evaluated using Monte Carlo simulations, and these methods are also applied to two real examples.

Results

The simulat

SUBMITTER: Lyu J 

PROVIDER: S-EPMC7382086 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature