Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators, and role in key physiological response.

ABSTRACT: The ability of Staphylococcus aureus to infect many different tissue sites is enabled, in part, by its transcriptional regulatory network (TRN) that coordinates its gene expression to respond to different environments. We elucidated the organization and activity of this TRN by applying independent component analysis to a compendium of 108 RNA-sequencing expression profiles from two S. aureus clinical strains (TCH1516 and LAC). ICA decomposed the S. aureus transcriptome into 29 independently modulated sets of genes (i-modulons) that revealed: 1) High confidence associations between 21 i-modulons and known regulators; 2) an association between an i-modulon and σS, whose regulatory role was previously undefined; 3) the regulatory organization of 65 virulence factors in th

SUBMITTER: Poudel S 

PROVIDER: S-EPMC7382225 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature