Label-free optical detection of bioelectric potentials using electrochromic thin films.

ABSTRACT: Understanding how a network of interconnected neurons receives, stores, and processes information in the human brain is one of the outstanding scientific challenges of our time. The ability to reliably detect neuroelectric activities is essential to addressing this challenge. Optical recording using voltage-sensitive fluorescent probes has provided unprecedented flexibility for choosing regions of interest in recording neuronal activities. However, when recording at a high frame rate such as 500 to 1,000 Hz, fluorescence-based voltage sensors often suffer from photobleaching and phototoxicity, which limit the recording duration. Here, we report an approach called electrochromic optical recording (ECORE) that achieves label-free optical recording of spontaneous neuroelectrical activities. E

SUBMITTER: Alfonso FS 

PROVIDER: S-EPMC7382226 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature