Original antigenic sin priming of influenza virus hemagglutinin stalk antibodies.

ABSTRACT: Immunity to influenza viruses can be long-lived, but reinfections with antigenically distinct viral strains and subtypes are common. Reinfections can boost antibody responses against viral strains first encountered in childhood through a process termed "original antigenic sin." It is unknown how initial childhood exposures affect the induction of antibodies against the hemagglutinin (HA) stalk domain of influenza viruses. This is an important consideration since broadly reactive HA stalk antibodies can protect against infection, and universal vaccine platforms are being developed to induce these antibodies. Here we show that experimentally infected ferrets and naturally infected humans establish strong "immunological imprints" against HA stalk antigens first encountered during primary infl

SUBMITTER: Arevalo CP 

PROVIDER: S-EPMC7382271 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature