Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library.

ABSTRACT: DNA-encoded chemical libraries are collections of compounds individually coupled to unique DNA tags serving as amplifiable identification barcodes. By bridging split-and-pool combinatorial synthesis with the ligation of unique encoding DNA oligomers, million- to billion-member libraries can be synthesized for use in hundreds of healthcare target screens. Although structural diversity and desirable molecular property ranges generally guide DNA-encoded chemical library design, recent reports have highlighted the utility of focused DNA-encoded chemical libraries that are structurally biased for a class of protein targets. Herein, a protease-focused DNA-encoded chemical library was designed that utilizes chemotypes known to engage conserved catalytic protease residues. The three-cycle library

SUBMITTER: Dawadi S 

PROVIDER: S-EPMC7382296 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature