Challenges and shifting treatment strategies in the surgical treatment of locally advanced rectal cancer.

ABSTRACT: The current standard treatment for locally advanced rectal cancer (LARC) in Korea and Western countries is a multimodal approach incorporating preoperative long-course chemoradiotherapy (LCRT) followed by total mesorectal excision (TME) and adjuvant chemotherapy. This approach has significantly improved local control and reduced recurrence rates; however, the overall survival benefit has not been established. Although LCRT is a good option, there remain challenging unresolved problems for colorectal surgeons. We focused on four challenging issues in this review article. The first is LARC with resectable liver metastases, for which there has been no consensus regarding optimal management and practice thus far. The second is cancer progression at the time of restaging after completion of pre

SUBMITTER: Kim HS 

PROVIDER: S-EPMC7382439 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature