Incorporating information from markers in LD with test locus for detecting imprinting and maternal effects.

ABSTRACT: Numerous statistical methods have been developed to explore genomic imprinting and maternal effects by identifying parent-of-origin patterns in complex human diseases. However, because most of these methods only use available locus-specific genotype data, it is sometimes impossible for them to infer the distribution of parental origin of a variant allele, especially when some genotypes are missing. In this article, we propose a two-step approach, LIMEhap, to improve upon a recent partial likelihood inference method. In the first step, the distribution of the missing genotypes is inferred through the construction of haplotypes by using information from nearby loci. In the second step, a partial likelihood method is applied to the inferred data. To substantiate the validity of the proposed p

SUBMITTER: Zhang F 

PROVIDER: S-EPMC7382457 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature