Systematic Characterization and Longitudinal Study Reveal Distinguishing Features of Human Milk Oligosaccharides in China.

ABSTRACT:

Background

Human milk oligosaccharides (HMOs) in breast milk contribute to the development of the neonatal microbiota and immune system. However, longitudinal studies examining HMO profiles of Chinese mothers remain scarce.

Objectives

We aimed to analyze HMO profiles, including their composition, concentrations, and changes during lactation, in milk of Chinese mothers.

Methods

A total of 822 milk samples from 222 mothers were collected, of which 163 mothers provided single samples. Samples from the remaining 59 mothers were collected on day 3, day 7, and thereafter every 7 or 14 d until day 168. 24 HMOs were studied using high-performance anion-exchange chromatography. Secretor and nonsecretor status were determined based on Lewis blood types and a defined 2'-fucosyll

SUBMITTER: Wu J 

PROVIDER: S-EPMC7382630 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature