Whole genome sequencing of macrolide resistant Streptococcus pneumoniae serotype 19A sequence type 416.

ABSTRACT:

Background

The resistance of Streptococcus pneumoniae to macrolides is becoming an increasingly important issue and thus it is important to understand the genetics related to adaptation of this species to the widespread use of antibiotics in Europe. The 58 isolates of S. pneumoniae belonging to sequence type (ST) 416 and serotype 19A and to several different phenotypes originated from Italy, Portugal and Czech Republic were thus sequenced on Illumina MiSeq. The aim of the study was to describe genetical origine of isolates, investigate their macrolide resistance and suggest reasons for spread of ST416 in the Czech Republic.

Results

Investigation of genes associated with serotype determined serotype switch between 15B and 19A serotypes and core genome multilocus sequence typi

SUBMITTER: Spanelova P 

PROVIDER: S-EPMC7382794 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature