Microbiota from alginate oligosaccharide-dosed mice successfully mitigated small intestinal mucositis.

ABSTRACT:

Background

The increasing incidence of cancer and intestinal mucositis induced by chemotherapeutics are causing worldwide concern. Many approaches such as fecal microbiota transplantation (FMT) have been used to minimize mucositis. However, it is still unknown whether FMT from a donor with beneficial gut microbiota results in more effective intestinal function in the recipient. Recently, we found that alginate oligosaccharides (AOS) benefit murine gut microbiota through increasing "beneficial" microbes to rescue busulfan induced mucositis.

Results

In the current investigation, FMT from AOS-dosed mice improved small intestine function over FMT from control mice through the recovery of gene expression and an increase in the levels of cell junction proteins. FMT from AOS-dosed

SUBMITTER: Zhang P 

PROVIDER: S-EPMC7382812 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature