A panel of DNA methylation signature from peripheral blood may predict colorectal cancer susceptibility.

ABSTRACT:

Background

Differential DNA methylation panel derived from peripheral blood could serve as biomarkers of CRC susceptibility. However, most of the previous studies utilized post-diagnostic blood DNA which may be markers of disease rather than susceptibility. In addition, only a few studies have evaluated the predictive potential of differential DNA methylation in CRC in a prospective cohort and on a genome-wide basis. The aim of this study was to identify a potential panel of DNA methylation biomarkers in peripheral blood that is associated with CRC risk and therefore serve as epigenetic biomarkers of disease susceptibility.

Methods

DNA methylation profile of a nested case-control study with 166 CRC and 424 healthy normal subjects were obtained from the Gene Expression Omnibu

SUBMITTER: Onwuka JU 

PROVIDER: S-EPMC7382833 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature