Long-acting injectable cabotegravir for the prevention of HIV infection.

ABSTRACT:

Purpose of review

This review highlights the development of long-acting injectable cabotegravir (CAB LA) for HIV preexposure prophylaxis (PrEP), with a focus on phase 2 studies and later development.

Recent findings

Early studies of CAB LA for HIV prevention offered promising pharmacokinetic data and paved the way for phase 2 studies, which have now been completed. On the basis of phase 2 data, dosing of CAB LA at 8-week intervals consistently delivers target trough concentrations in both men and women. Recent studies have shown no required dose adjustments for hepatic or renal disease and minimal drug--drug interactions. Additionally, injectable PrEP is desired by potential PrEP candidates. Still, gaps in knowledge remain with respect to implementation and delivery, the cli

SUBMITTER: Clement ME 

PROVIDER: S-EPMC7382946 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature