Genome-wide estimates of heritability and genetic correlations in essential tremor.

ABSTRACT:

Introduction

Despite considerable efforts to identify disease-causing and risk factors contributing to essential tremor (ET), no comprehensive assessment of heritable risk has been performed to date.

Methods

We use GREML-LDMS to estimate narrow-sense heritability due to additive effects (h²) and GREMLd to calculate non-additive heritability due to dominance variance (δ²) using data from 1,751 ET cases and 5,311 controls. We evaluate heritability per 10 Mb segments across the genome and assess the impact of Parkinson's disease (PD) misdiagnosis on heritability estimates. We apply genetic risk score (GRS) from PD and restless legs syndrome (RLS) to explore its contribution to ET risk and further assess genetic correlations with 832 traits by Linkage diseq

SUBMITTER: Diez-Fairen M 

PROVIDER: S-EPMC7382955 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature