Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer.

ABSTRACT:

Objective

To investigate the function of a novel primate-specific long non-coding RNA (lncRNA), named FLANC, based on its genomic location (co-localised with a pyknon motif), and to characterise its potential as a biomarker and therapeutic target.

Design

FLANC expression was analysed in 349 tumours from four cohorts and correlated to clinical data. In a series of multiple in vitro and in vivo models and molecular analyses, we characterised the fundamental biological roles of this lncRNA. We further explored the therapeutic potential of targeting FLANC in a mouse model of colorectal cancer (CRC) metastases.

Results

FLANC, a primate-specific lncRNA feebly expressed in normal colon cells, was significantly upregulated in cancer cells compared with normal colon samples in

SUBMITTER: Pichler M 

PROVIDER: S-EPMC7382985 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature