Prediction of air trapping or pulmonary hyperinflation by forced spirometry in COPD patients: results from COSYCONET.

ABSTRACT:

Background

Air trapping and lung hyperinflation are major determinants of prognosis and response to therapy in chronic obstructive pulmonary disease (COPD). They are often determined by body plethysmography, which has limited availability, and so the question arises as to what extent they can be estimated via spirometry.

Methods

We used data from visits 1-5 of the COPD cohort COSYCONET. Predictive parameters were derived from visit 1 data, while visit 2-5 data was used to assess reproducibility. Pooled data then yielded prediction models including sex, age, height, and body mass index as covariates. Hyperinflation was defined as ratio of residual volume (RV) to total lung capacity (TLC) above the upper limit of normal. (ClinicalTrials.gov identifier: NCT01245933).

SUBMITTER: Alter P 

PROVIDER: S-EPMC7383055 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature