Biology of the Triple-Negative Breast Cancer: Immunohistochemical, RNA, and DNA Features.

ABSTRACT:

Background

The triple-negative breast cancer (TNBC) constitutes a heterogeneous disease with an aggressive behavior and a poor prognosis. A better understanding of its biology is required to identify new biomarkers and improve clinical outcomes.

Summary

To date, the definition and classification of TNBC depends on a multiomic approach including immunohistochemistry (IHC), genomic, and transcriptomic features, and the tumor immune landscape. The development of new technologies has allowed us to sequence the whole cancer genome. The Cancer Genome Atlas (TCGA) and next-generation sequencing have led to a greater knowledge of DNA alterations such as TP53 or BRCA mutations, copy number variations, and DNA methylations. In addition, gene expression profiling has allowed to define

SUBMITTER: Herrera Juarez M 

PROVIDER: S-EPMC7383258 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature