The Interplay between Alcoholic Liver Disease, Obesity, and the Metabolic Syndrome.

ABSTRACT:

Background

Fatty liver may be the result of several factors. The two main contributors are nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD).

Summary

NAFLD is the hepatic manifestation of the metabolic syndrome (MetS) and is the major cause of chronic liver disease worldwide as a result of the obesity epidemic. ALD is also a common cause of chronic liver disease. Obesity is a major contributory factor to MetS and is also common in individuals who consume large amounts of alcohol. There is a similar hepatic pathology and both can result in severe fibrosis, cirrhosis, and its complications including hepatocellular carcinoma. This review discusses the etiology, pathogenesis, and genetics of both NAFLD and ALD and their interaction. It is necessary to un

SUBMITTER: Malnick S 

PROVIDER: S-EPMC7383260 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature