Lipocalin-1 Expression as a Prognosticator Marker of Survival in Breast Cancer Patients.

ABSTRACT:

Purpose

LCN1 (lipocalin-1), a gene that encodes tear lipocalin (or von Ebner's gland protein), is mainly expressed in secretory glands and tissues, such as the lachrymal and lingual gland, and nasal, mammary, and tracheobronchial mucosae. Analysis of the Cancer Genome Atlas (TCGA) Breast Carcinoma (BRCA) level 3 data revealed a relationship between LCN1 expression and survival in breast cancer patients.

Methods

The χ² test and Fisher exact test were applied to analyze the clinical data and RNA sequencing expression data, and the association between LCN1 expression and clinicopathologic features was determined. The receiver-operating characteristic (ROC) curve of LCN1 was drawn to assess its ability as a diagnostic marker, and the optimal cutoff value was obtained

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7383281 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature