Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system.

ABSTRACT: As the most prevalent and abundant transcriptional modification in the eukaryotic genome, the continuous and dynamic regulation of N6-methyladenosine (m6A) has been shown to play a vital role in physiological and pathological processes of cardiovascular diseases (CVDs), such as ischemic heart failure (HF), myocardial hypertrophy, myocardial infarction (MI), and cardiomyogenesis. Regulation is achieved by modulating the expression of m6A enzymes and their downstream cardiac genes. In addition, this process has a major impact on different aspects of internal biological metabolism and several other external environmental effects associated with the development of CVDs. However, the exact molecular mechanism of m6A epigenetic regulation has not been fully elucidated. In this review, we outline

SUBMITTER: Zhao K 

PROVIDER: S-EPMC7383322 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature