Tumor Regression Grade Predicts Survival in Locally Advanced Gastric Adenocarcinoma Patients with Lymph Node Metastasis.

ABSTRACT:

Background

Tumor regression grade (TRG) is widely used in gastrointestinal carcinoma to evaluate pathological responses to neoadjuvant chemotherapy (NCT), but whether it is an independent prognostic factor is still controversial. The aim of this study is to investigate the value of TRG in locally advanced gastric adenocarcinoma patients who underwent NCT and curative resection.

Methods

Pathological regression was reevaluated according to the Mandard TRG. Survival curves were obtained by the Kaplan-Meier method, and differences in overall survival (OS) and disease-free survival (DFS) were compared using the log-rank test. Univariate and multivariate analyses for survival were based on the Cox proportional hazards method.

Results

In total, 290 patients were identified i

SUBMITTER: Tong Y 

PROVIDER: S-EPMC7383330 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature