Expression of NANOG and Its Regulation in Oral Squamous Cell Carcinoma.

ABSTRACT:

Background

Results of previous studies suggest that NANOG may be an important prognostic biomarker in oral squamous cell carcinoma (OSCC), but there are contradictory results regarding NANOG expression patterns on mRNA and protein levels, and the mechanisms of its regulation are poorly understood. Our aim was to analyze the expression and diagnostic significance of NANOG in OSCC, and the possible mechanisms of its regulation, i.e., protein regulators on mRNA level (OCT4, SOX2, KLF4, AGR2, and NOTCH1), methylation status, copy number variation, and regulatory miRNAs, miR-145, miR-335, miR-150, miR-34a, miR-128, and miR-27a.

Methods

Our study included 120 patients with OSCC. Expression of NANOG protei

SUBMITTER: Grubelnik G 

PROVIDER: S-EPMC7383335 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature