Initiating factors for the onset of OA: A systematic review of animal bone and cartilage pathology in OA.

ABSTRACT: There is controversy over whether bone or cartilage is primarily involved in osteoarthritis (OA) pathogenesis; this is important for targeting early interventions. We explored evidence from animal models of knee OA by preforming a systematic review of PubMed, Scopus, and Web of Science for original articles reporting subchondral bone and cartilage pathology in animal models with epiphyseal closure. Extracted data included: method of induction; animal model; cartilage and bone assessment and method; meniscal assessment; skeletal maturity; controls; and time points assessed. Quality scoring was performed. The best evidence was synthesized from high-quality skeletally mature models, without direct trauma to tissues of interest and with multiple time points. Altogether, 2849 abstracts were rev

SUBMITTER: Casper-Taylor ME 

PROVIDER: S-EPMC7383628 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature