Conservative management of women with cervical intraepithelial neoplasia grade 2 in Denmark: a cohort study.

ABSTRACT: OBJECTIVE:Assess the progression, persistence, and regression of cervical intraepithelial neoplasia grade 2 (CIN2) after new guidelines on conservative treatment, compared with previous practice. DESIGN:Nationwide register-based cohort study. SETTING:Denmark. POPULATION:Women aged 18-44 years diagnosed with CIN2 on biopsy: 6721 in 2008-2011 and 6399 in 2014-2017. METHODS:Register data were retrieved from before (2008-2011) and after (2014-2017) the introduction of new guidelines. Histology diagnoses at second visit were used to assess progression (CIN3+), persistence (CIN2), or regression (CIN1/normal). MAIN OUTCOME MEASURES:Proportion of CIN2 by type of management. Relative risk (RR) and corresponding 95% confidence intervals (95% CIs) for progression, persistence, and regression at secon

SUBMITTER: Skorstengaard M 

PROVIDER: S-EPMC7383715 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature