Evaluation of subchronic administration of antiseizure drugs in spontaneously seizing rats.

ABSTRACT:

Objective

Approximately 30% of patients with epilepsy do not experience full seizure control on their antiseizure drug (ASD) regimen. Historically, screening for novel ASDs has relied on evaluating efficacy following a single administration of a test compound in either acute electrical or chemical seizure induction. However, the use of animal models of spontaneous seizures and repeated administration of test compounds may better differentiate novel compounds. Therefore, this approach has been instituted as part of the National Institute of Neurological Disorders and Stroke Epilepsy Therapy Screening Program screening paradigm for pharmacoresistant epilepsy.

Methods

Rats were treated with intraperitoneal kainic acid to induce status epilepticus and subsequent spontaneous recu

SUBMITTER: Thomson KE 

PROVIDER: S-EPMC7383749 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature