Risk factors for second-line dactinomycin failure after methotrexate treatment for low-risk gestational trophoblastic neoplasia: a retrospective study.

ABSTRACT:

Objective

To find risk factors for second-line dactinomycin failure in patients with low-risk gestational trophoblastic neoplasia (GTN).

Design

Retrospective multicentre study.

Setting

Tertiary reference centre.

Population

Patients with low-risk GTN, treated with dactinomycin after methotrexate (MTX) failure.

Methods

Retrospective analysis of 45 patients with low-risk GTN treated with dactinomycin after MTX failure, registered between 2006 and 2018.

Main outcome measures

Treatment outcome and risk factors for second-line dactinomycin failure.

Results

Thirty patients (66.7%) were cured and 15 patients (33.3%) required third-line therapy. Type of antecedent pregnancy and hCG levels pre-dactinomycin were risk factors for failure in univariate

SUBMITTER: Hoeijmakers YM 

PROVIDER: S-EPMC7383780 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature